Define-AI Directory

Our use cases are scenarios where use of artificial intelligence (AI) may help improve medical imaging care.

They were created to empower AI developers to produce algorithms that are clinically relevant, ethical, and effective. Each use case provides narrative descriptions and flow charts which specify the health care goal of the algorithm, the required clinical input, how it should integrate into the clinical workflow and how it will interface with users and tools.

Our use cases help radiologists and allied professionals by ensuring that AI tools provide needed information, can be efficiently implemented into daily workflow, and have the potential to improve the quality and efficiency of patient care.


Acute Appendicitis
Detect acute appendicitis

Colon Polyp Detection

Detect polyps greater than six millimeters

Breast Imaging

Classifying Suspicious Microcalcifications
Automate classification of breast microcalcifications into categories based on level of suspicion at time of diagnostic mammography

Breast Density Quantification
To automate the assessment of breast density on digital mammography and digital breast tomosynthesis by developing an AI tool that: (1) assigns a BI-RADS breast composition category, (2) assigns a composite numeric breast density score, and (3) provides regional breast density numeric sub-scores


Aortic Valve Analysis
Automate aortic valve measurements  

Ascending Aortic Diameter
Automate ascending aortic diameter measurement

Cardiac Output
Calculate cardiac output
#LV Functional Assessment

Detect cardiomegaly on posterioranterior and anteroposterior radiographs
#Cardiac Size on Chest Radiograph

Cardiothoracic Ratio
Measure cardiothoracic ratio on posterioranterior and anteroposterior radiographs
#Cardiac Size on Chest Radiograph

Carina Angle Measurement
Measure angle of carina
#Cardiac Size on Chest Radiograph

Coronary Flow Reserve on PET
Automate measurement of myocardial blood flow and coronary flow reserve (CFR) on PET

Flow in Ascending Aorta
Automate measurement of flow in ascending aorta

Flow in Pulmonary Artery
Automate measurement of flow in pulmonary artery

Left Atrial Enlargement
Detect left atrial enlargement
#Cardiac Size on Chest Radiograph

Left Atrial Size
Automate measurement of left atrial size on CT

Left Ventricle Late Gadolinium Enhancement Assessment for MR
Automate late gadolinium enhancement assessment

Left Ventricle Myocardial Mass
Measure myocardial mass on left ventricle
#LV Functional Assessment

Left Ventricle T1 Mapping Quantification
Report quantitative left ventricle myocardial T1 relaxation time, before and after IV contrast. Use these values to compute extracellular volume.

Left Ventricle Volume

Automate standard left ventricle volumetric measurements
#LV Functional Assessment

Left Ventricle Wall Motion
Automate standard left ventricle wall motion assessment
#LV Functional Assessment

Left Ventricle Wall Thickening
Automate left ventricle wall thickening assessment
#LV Functional Assessment

Left Ventricle Wall Thickness Measurement
Automate standard left ventricle wall thickness measurements
#LV Functional Assessment

Left Ventricular Late Gadolinium Enhancement Assessment for MR
Automate late gadolinium enhancement assessment

Myocardial Perfusion Quantification for CT
Automatic quantification and classification of myocardial perfusion

Pulmonary Artery Diameter
Automate pulmonary artery size measurements

Pulmonary Artery to Aortic Diameter Ratio
Calculate MPa:Ao and determined if enlarged

Pulmonary to Systemic Flow Ratio
Automate measurement of pulmonary to systemic flow ratio (Qp:Qs)

Pulmonary Veins Mapping Preablation Planning for CT
Document pulmonary veins and anatomy for ablation planning on CT

TAVR Aortic Root Measurements
Automate aortic root and cardiac measurements for transcatheter aortic valve replacement (TAVR) necessary to determine the size and type of valve best for the patient.


Accessory Muscles Causing Neurovascular Compromise
Identify the presence of an accessory muscle

Chrondral Bone Lesion Characterization

Provide a probability of a chondral bone lesion having benign vs. malignant potential

Hip Osteolysis
Measure osteolysis in the hip following total hip arthroplasty

Hip Subsidence

Measure subsidence in the hip following total hip arthroplasty

Ligamentum Teres Injury Detection
Ligamentum teres injury detection

Odontoid Fracture
Detect odontoid fracture on cervical spine trauma radiographs

Osteochrondritis Dissecans
Determine stability of osteochondritis dissecans

Pediatric Elbow
Assist radiologists in the interpretation of pediatric elbow radiographs

Periprosthetic Hip Fracture
Detect periprosthetic hip fracture

Periprosthetic Hip Lucency
Measure periprosthetic lucency in the hip

Radial Head Dislocation
Detect radial head dislocation

Slipped Capital Femoral Epiphysis
Assist radiologists in the interpretation of pediatric hip radiographs

Soft-Tissue Tumor Bed Size Change
Detect and quantify volumetric changes of a soft-tissue tumor

Stener Lesion
Detect status of ulnal collateral ligament and presence of a Stener lesion

Tarsal Coalition

Detect, characterize, and classify tarsal coalitions

Tarsometatarsal Joint Status
Detect if Lisfranc joint is normal or abnormal

Trauma Fracture Detection
Detect all fractures on CT chest, abdomen, and pelvis performed for trauma


Midline Shift
Detect and measure midline shift

Motor Cortex Quantitative Susceptibility Mapping
Quantification of QSM of motor cortex and segmentation


Extranodal Extension
Detect/delineate lymph node involvement and extranodal extension on cross-sectional images


Quantify the presence and change of scoliosis measurements


Detection of pneumonia on chest radiograph in adults

Detection and quantification of pneumothorax on chest radiograph